Influence of time-restricted feeding schedule on daily rhythm of abcb1a gene expression and its function in rat intestine
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چکیده
214 words Introduction; 488 words Discussion; 931 words d) Abbreviations: ADx, adrenalectomized; DBP, D-site biding protein; E4BP4, E4 promoter binding protein-4; HLF, hepatic leukemia factor; P-gp, P-glycoprotein; ZT, zeitgeber time e) Recommended section: Metabolism, Transport and Pharmacogenomics This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on July 28, 2010 as DOI: 10.1124/jpet.110.170837 at A PE T Jornals on July 0, 2017 jpet.asjournals.org D ow nladed from
منابع مشابه
Influence of a time-restricted feeding schedule on the daily rhythm of abcb1a gene expression and its function in rat intestine.
P-glycoprotein (P-gp) is one of the ATP-binding cassette transporters and acts as an efflux pump for cytotoxic substances. P-gp mRNA expression and transporting activity show the daily rhythm and contribute to the chrono-pharmacokinetic profiles of many drugs. It is reported that the daily rhythm of abcb1a mRNA is regulated by a circadian clock-controlled output pathway. Time-restricted feeding...
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